Alcohol Inhibits NR2B-Containing NMDA Receptors in the Ventral Bed Nucleus of the Stria Terminalis
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چکیده
منابع مشابه
NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis
Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSU...
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Background: The areas of the bed nucleus of the stria terminalis (BST) with a high density of estrogen receptors are involved in cardiovascular regulation and send axonal projections to the rostroventrolateral medulla (RVLM). We aimed to find the contribution of the RVLM to cardiovascular responses elicited by glutamate microinjection into the BST. Methods: Experiments were done in α-ch...
متن کاملGABAergic receptors in rostral ventrolateral medulla mediates the cardiovascular responses to activation of bed nucleus of the stria terminalis in the female rat
The bed nucleus of the stria terminalis (BST) is known to contain estrogen (E)- concentrating neurons. In addition, injections of E into BST have been reported to potentiate the sympathoinhibitory arterial pressure (AP) and heart rate (HR) responses elicited by glutamate (Glu) stimulation. In this study, the effect of GABA-A antagonist receptors, bicuculline methiodide (BMI), in the rostral ven...
متن کاملPresynaptic muscarinic M(2) receptors modulate glutamatergic transmission in the bed nucleus of the stria terminalis.
The anterolateral cell group of the bed nucleus of the stria terminalis (BNST(ALG)) serves as an important relay station in stress circuitry. Limbic inputs to the BNST(ALG) are primarily glutamatergic and activity-dependent changes in this input have been implicated in abnormal behaviors associated with chronic stress and addiction. Significantly, local infusion of acetylcholine (ACh) receptor ...
متن کاملRole of GABAA receptors of bed nucleus stria terminalis in controlling of blood pressure and heart rate in rats
Introduction: The Bed nucleus stria terminalis (BST) is a part of the limbic system. It was recently shown that chemical stimulation of the BST by L-glutamate elicited cardiovascular depressive responses. In the present study, we have investigated the possible cardiovascular role of the GABAergic receptors in BST by microinjection of its agonist and antagonists. Methods: Experiments were p...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2007
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1301504